RT Journal Article SR Electronic A1 Konečný, Petr A1 Sedláček, Petr A1 Tarasová, Martina T1 The Influence of Combinations Air-splinting and Botulinum Toxin-A Therapy to Changes in Spasticity of the Hand JF Profese Online YR 2017 VO 10 IS 1 SP 22 OP 27 DO 10.5507/pol.2017.004 UL https://profeseonline.upol.cz/en/artkey/pol-201701-0004.php AB Background: Spastic paresis of the hand causes problems in the grip and manipulative function of hand in activities of daily living, hygiene, nursing and rehabilitative care, detriorations in quality of life and it also causes pain. Reduction or elimination of spasticity is one of the fundamental tasks of the rehabilitation of spastic paresis of the hand after cerebrovascular disease (stroke). Aim: The aim is to describe the combined effect of botulinum toxin-A and air-splinting in patients after stroke with spastic paresis of hand. Methods: This was a prospective observational cohort study describing an association between reduction of spasticity and splinting with air-splints (experimental cohort of 20 patients, 16 women, 14 men, mean age 59.5 ± 9.8 years) versus conventional rehabilitation with progressive stretching of spastic muscles (control cohort of 20 patients, 18 women, 12 men, mean age 60.0 ± 9.5 years). All patients had postictal spastic paresis of hand, therapy with botulinum toxin-A and six-week rehabilitation. The measured data were statistically evaluated at the significance level p < 0.05 using Student's t-test, Mann-Whitney U test, Chi quadrate and logistic regression analysis. Results: Forty patients (20 experimental and 20 control) completed the observational study. After six week of therapy was demonstrated very significant association of air-splint therapy and alleviation spasticity of hand - Odds Ratio: 4.0 (95% CI: 3.5 to 5.0) and significant association of conventional rehabilitation (progressive stretching) and alleviation spasticity of hand - Odds Ratio: 1.5 (95% CI: 1.1 to 2.0). Conclusions: In our study has been described more significant relationship between the reduction in spasticity of the hand and therapy with use botulo toxin-A and air splint versus therapy with botulinum toxin-A and conventional rehabilitation with progressive stretching.